Panchakarma is Ayurveda’s primary purification and detoxification treatment. Panchakarma means “five therapies”. These 5 therapeutic treatments eliminate toxins from the body, they are : Vamana, Virechana, Nasya, Basti and Raktamoskshana. The series of these five therapies help remove deep rooted stress and illness-causing toxins from the body while balancing the doshas (energies that govern all biological functions).

 Vamana Karma: Vamaka dravyas get quickly absorbed in blood and cross the blood brain barriers and stimulates the vomiting centerand result into vomiting due to Usna, Tikshana, Sukshama, Vyavayi, Vikasi, Urdhavabhagha prabhava properties.Vamana Karma, also known as medical vomiting,It is one of the five Pradhana Karmas of Panchakarma which is used in treating Kaphaj disorders.

The expelled material consists of undigested food, Kapha Dosha& Pitta dosha. The vitiated Kapha dosha is expelled out through the mechanism of Vamana Karma and the disease process is stopped

Virechana Karma: The drugs which are Ushna, tikshana, Sukshma, vyavayi and vikashi reach to the heart (hridaya) by virtue of their virya and prabhava, circulate through the micro & macro channels due to its sukshma and vyavayi properties and pervade the entire body. Then they liquefy (vishyandana) the dosha samghata by virtue of their Ushana guna and flaccid it and break it up (chhedana) by their tikshana and vikashi guna. The vitiated Pitta dosha is expelled out through the mechanism of Vamana Karma and the disease process is stopped

In the present study, Vamana and Virechana along with palliative treatment was given to patients of Sthula Prameha (Diabetes mellitus or DM). An attempt was made to compare and evaluate the role of Shodhana therapy (Vamana and Virechana). Total 47 patients of Sthula Pramehi were registered in this study, out of which 38 completed the treatment. The patients were divided into two groups, viz. Vamana with Shamana (Group A) and Virechana with Shamana (Group B). Eighteen patients completed the treatment in Group A and 20 in Group B. Neem giloy satva capsule was used as Shamana drug at a dose of 500 mg twice daily after meals for 30 days in both the groups. The efficacy of therapy was assessed based on relief in cardinal signs and symptoms and blood sugar, lipid profile and other biochemical parameters etc. The results showed that the Vamana provided better relief in signs and symptoms as well as on fasting blood sugar (FBS) and postprandial blood sugar (PPBS) in comparison to Virechana..